LIFESCI 7A Lecture Notes - Lecture 8: Tim Barrel, Endomembrane System, Protein Folding
Document Summary
Week 6 notes: protein evolution and sorting notes. Protein evolution and the origin of new proteins. Protein family: group of structurally/functionally related proteins as a result of shared evolutionary history. Most proteins are made of modular folding domains. Folding domain: region of protein that folds in a similar way relatively independently of the rest of the protein (there are small regions of 3d structure where protein folding is similar) Ex: tim barrel (loops at carboxyl ends of sheets) and barrel (antiparallel. Proteins prob started out short and not that much function. Protein families are composed of diff combos of folding domains. Amino acid sequences evolve thru mutation and selection: mutation: change in sequence of a gene occurs at random in regard to their effects on protein function. Some may affect amino acid sequence, some may change level of protein expression or other stuff.
