LIFESCI 3 Lecture Notes - Lecture 10: Transposable Element, Gene Duplication, Noncoding Dna
Document Summary
Background: chromatin remodeling, purposes, manipulating the dna to allow for gene expression, manipulating the dna for cell division. Genome breakdown: protein-coding genes, only ~1. 5% of the genome, repetitive sequences, comprise a majority of the genome, but the purpose of most of them is unknown. Exons: definition: what"s maintained in the mrna that gets translated. Other types of repetitive sequences: long repetitive sequences, centromeres, center of chromosome, telomeres, segment duplications, simple-sequence repeats, ltr retrotransposons, sines, lines. Chromatin in eukaryotic chromosomes: organization of eukaryotic chromosomes (highest lowest, mitotic chromosome, condensed section of chromosome, chromatin has a lot of protein (i. e. cohesins, scaffold proteins) & Modifications that affect charge of histone tails: without such modifications: differently, dna: negatively charged, histone tail has many positively charged amino acids, ex. Lysine: result: positively charged amino acids & dna are tightly bound, types, methylation, ex. Arginine, lysine: doesn"t change the positive charge, acetylation, ex.
