LIFESCI 2 Lecture Notes - Lecture 24: Sister Chromatids, Nuclear Membrane, Kinetochore

• School: UCLA
• Department: Life Sciences
• Course: LIFESCI 2
• Professor: Arnold, A.P., Esdin, J.

Document Summary

Linear dna molecules that are associated with proteins called histones. During duplication, sister chromatids attach to each other thru centromere, when done. Eukaryotes have two copies of each chromosome chromatids separate: mitotic cell cycle. Nucleolus(manufacture ribosome), nuclear envelope start to disappear. Mitotic spindles begin to form -> microtubule begin to produce. Kinetochores/kinetochore microtubule formation on centromere (protein found on centromere. Centrioles move to opposite poles of cell: metaphase. Non-kinetochore microtubules help more to stabilize cell during process kinetochore microtubules. Motor protein of the kinetochore of the chromosome walks along the microtubule pulling the chromosome with it. Microtubules passed by motor protein breaks down. Microfilaments (made of contractile protein actin, powered by motor proteins) form and contract to constrict the cell in the middle until the two cells separate: regulation. Internal checkpoints & external factors (hormones and growth factors) Level constant regulated by protein kinase & phosphatase.