GE CLST M71A Lecture Notes - Lecture 5: Progestin, Genotoxicity, Menopause

• School: UCLA
• Department: General Education Clusters
• Course: GE CLST M71A
• Professor: Rensel, M.A.; Le Goff, A.G.; Panofsky, A.L.

Document Summary

Lecture notes: breast cancer epidemiology and environmental inputs: estrogens/hormones as. Jessica is a carrier of brca1 mutation; does this guarantee that she will develop cancer. Mutated tumor suppressor genes are recessive therefore both copies need to be mutated to lose function. If she only has one mutated copy, she will not develop cancer. If the viable copy is lost/mutates in a cell, cancer may develop (could reference the 2-hit hypothesis) Any type of mutation in the brca2 gene will lead to loss of protein function; t/f explain. Different types of mutations have different effects on protein structure and function. Silent mutations, in which one nucleotide changes, have no effect on the amino acid protein. Missense (point), nonsense (point), and frameshift (multiple nucleotide insertions or deletions) mutations have the potential to influence protein function by changing the amino acid makeup of the protein. How do we study cancer/other disease: monitor the dist.