GE CLST 73A Lecture Notes - Lecture 8: Volt, Millisecond, Lidocaine

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Negative to positive value across the membrane. We need an action potential for cellular communication. Hodgkin cycle - voltage channels start opening. When they close, you lose your current = repolarization. Voltage k channel lags, it takes slower time to open. The ena is positive, which makes the action potential go positive. Chemical gradient is out to in, which makes the action potential positive. Graded/synaptic potentials are for short term propagation. Most of the cells in the brain are unmyelinated. Na+ is positive, everything is negative, so it flows. Cation flow, rearranges charge to get depolarization. We will never get a backward action potential. Myelin does not allow the current to leak. No voltage gated channels in the myelinated region. Passive current mimics the shape of the action potential. Fastest conduction: motoneurons, sensory neurons (100 m/s) Instead of using myelinated axons, they have giant axon diameter. Frog slows down when put in cold water.

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