CH ENGR 104C Lecture Notes - Lecture 9: Tetrahedral Carbonyl Addition Compound, Hemiacetal, Deprotonation
7 Feb 2017
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Images and sample reactions taken from the chemistry 14d. Organic chemistry by paula yurkanis bruice 4th edition. When dealing with carbonyls, we consider two general mechanism types: 3a) if x is a leaving group, then you kick out the leaving group and the result is a substitution reaction: we start with the carbonyl which is attacked by the nucleophile. 2) we then get a tetrahedral intermediate whose fate is determined by the presence of a leaving group. 3b) if x is not a leaving group, the o- accepts a. H+ and the result is an addition reaction. Nitrile (rcn) (doesn"t look like a carbonyl because it doesn"t have a c=o but it reacts very similarly) h3c c=n. C= o survey of reactions: hemiacetal/acetal and. Ketone hemiketal ketal: ketone/aldehyde + alcohol = hemiacetal/hemiketal after one equivalent of alcohol. If you take a hemiacetal and replace the oh with an or" group then you get an acetal. i. e. ro c or".
