PCB 3703C Lecture Notes - Lecture 3: Loose Connective Tissue, Elastic Fiber, Extracellular Fluid
27 Aug 2016
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Document Summary
Gap junction: acts as channel for ions: required for myocardial tissue, mutation or alteration of gap junction can cause some disorders. Connective tissue: supports and binds other tissues, has cells scattered throughout an extracellular matrix, loose connective tissue. Any mutation to gene structure on chromosome 15 which leads to irritation of elastic fiber in connective tissue. Disproportionate long limbs, long thin fingers, relatively tall stature. Chromosome 15 holds fibrillin-1 which is essential for formation of the elastic fibers in connective tissue: ehlers-danlos syndrome. Collagen 1 and collagen 3 defect and give extreme elasticity to joint and skin. Body fluids: approximately 67% of total weight is water, remaining 33% is extracellular compartment, 20% of extracellular fluid is contained in vessels of the cardiovascular system. Extracellular matrix: blood vessels and interstitial space (located between blood vessels and all, composed of collagen, polysaccharides, and integrin. Factors which support the cell and important in adhesion of blood vessels: integrins.
