PCB 3703C Lecture Notes - Lecture 1: Endoplasmic Reticulum, Synapsis, Intellectual Disability

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Nuclear envelope: covers the nucleus externally. continues with lumen of rough and endoplasmic reticulum. Chromatin and chromosomes: 46 chromosomes (23 is paternal from father and 23 is maternal from mother) Before cell division there is interphase which has 3 steps. G1 (gap 1): the size of cell increases. S (synthetic) phase: duplication or replication of dna. G2 (gap 2): secretion of some enzymes which are required for cell division. Prophase: some microtubules are connected to chromosomes which is call kinetochores. Metaphase: they stay in one line and then form metaphase plate. Telophase: one cell becomes 2 cells (before telophase one cell has 2 nuclei for a shore time which is called cytokinesis) Meiosis 1: synapsis, crossing over, alignment, disjunction, cell division. Meiosis 2: synapsis, crossing over, alignment, disjunction, cell division. Down syndrome - extra chromosome 21 (mother being older in age can impact chance of child having down syndrome)

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