PCB 3233 Lecture Notes - Lecture 2: Mannose Receptor, Cd14, Tlr3
2 Apr 2020
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Chapter 3: when mannose receptor, cr3 and cr4, or scavenger receptors are engaged what mechanism is initiated in a phagocyte. Tlr-7: single stranded viral rna: explain tlr4 signaling mechanism. When lps is released, cd14 (co-receptor to tlr-4) binds to macrophage surface. Then md2 binds and forms a complex with tlr-4, cd14, and lps. This causes intracellular tir domain of tlr-4 to bind to myd88 protein. Activation of ikk activates transcription for factor kb (nfkb). By phosphorylating ikb, ikk causes nfkb to be released and it moves to the nucleus. Hematopoietic stem cell > common myeloid precursor > granulocyte- Tertiary/gelatinase: respiratory burst associated with neutrophils. Mannose binding lectin (mlb): activates lectin complement cascade: know all 3 complement pathways. What has to be present for them to start, the initiating enzyme and all the following components cut in order. Review from last exam: name of the complement convertases and their components. Classical & lectin: c4b2a: type i interferons vs.
