PCB 3233 Lecture Notes - Lecture 1: Edward Jenner, Lipopolysaccharide, Typhoid Fever
Document Summary
Extracellular (nutrients) and intracellular (infect using hosts) Outer membrane containing lipopolysaccharide (lps) (receptor detection) People who survive speci c infection develop immunity. To provide protective immunity, immune sys must engage microorganism. Lag time between infection and protection (~ 7 days) Disease prevented by prior exposure to infectious agent. Variolation: used to introduce a disease mildly in order to prevent more severe case of disease. Any organism with potential to cause disease. Opportunistic pathogens: cause disease when defenses are low or end up in a part of body not usually found. Constant evolutionary struggle between host and pathogen. Ex: bacteria, virus, fungi, parasites (protozoa & worms) Lysozyme in tears and saliva - antibacterial. Defensins - poke holes in the pathogen. When skin and mucosal barriers breached, immune system reacts. Innate = determined by genes you inherited. Adaptive cells (t and b change genes for receptors)
