CBNS 108 Lecture Notes - Lecture 14: Axon Guidance, Neuroblast, Growth Cone
27 Feb 2020
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Document Summary
Cbns 108: axon guidance, synapse formation, and refinement. Combinations of cues establish the physical wiring of the cns. Neural identity: determines fates of progenitores before they"ve even met maturity, patterning genes turning on in accordance with competitive activation factors, and other things, combinatorial expression, how it plays a role in wiring and protein expression. Migration: neural precursors migrate radially outward on these radial glial cells to form the layers of the central nervous system. This is a ring (going inside outside: migrate upward in the diagrams. Axonal outgrowth, guidance and synapses: unique to the nervous system. Continuation and conclusion of previous lecture: axon guidance, synapse formation and refinement of. During axon outgrowth and targeting, neurons form more synapses than needed. Further refinement occurs until zone is left (that is initially targeted). the cns: how are certain synapses selected to be stabilized, strongest type of cadherin to cadherin, cell-to-cell contact. Cbns 108: gene expression, determination and differentiated state.
