CBNS 108 Lecture Notes - Lecture 2: Pattern Formation, Cadherin, Body Plan
27 Feb 2020
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Cbns 108: localized maternal determinants guide drosophila development. Fundamental principles of early development, gastrulation, and maternal determinants. For the drosophila, they do not have the cleavage of the pm like other organisms. Figure 2: continuing to break symmetry and uniformity as the path continues on. Trying to get cells into different germ layers. Embryo develops more segmented regions: this groups the cells into different areas and can differentiate into different structures/jobs. The body plan develops based off of the a-p and d-v axis established by maternal determinants. These determinants are set up early on from maternal signals. Identities = pattern formation: key part of the pattern formation is setting up these axis of the embryo, d, v, a, p. This help comes from the cadherin proteins: cadherins are all localized on this area, oskar + nanos - oskar links to nanos later on. Establishes this nano gradient: oskar - mother. Links the two together: nurse cells deposit the determinants.
