CBNS 108 Lecture Notes - Lecture 1: Gastrulation, Mutagen, Wild Type
26 Feb 2020
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Discussion questions: what are the advantages of having nuclei share a cytoplasm early in development, more efficient movement, all sharing the same cytoplasm, all exposed to different signaling factors! Folding to the inside of the developing zygote. Mesoderm and endoderm are the two lineages: breaks symmetry of the anterior and posterior axis. Stalk connects mature and less mature egg chamber (older and younger). Forward: seeks to identify a gene or genes responsible for a phenotype (starts with a known phenotype), random mutagenesis, reverse, seeks to find the identity. Three classes of maternal effect genes are involved in patterning the drosophila a-p axis: anterior genes: required for patterning of anterior segments, posterior genes: required for patterning of posterior segments (abdomen). A: the mother has a normal copy of the gene (m), therefore all her embryos will develop normally. The genotypes of the embryos are irrelevant for maternal effect genes. Neither m/m nor m/m embryos will have a patterning effect!
