NUT 10 Lecture Notes - Lecture 17: Coronary Artery Disease, Monounsaturated Fat, Polyunsaturated Fat

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10 Aug 2018

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Metabolic syndrome & high blood cholesterol impact on heart disease risk. Abdominal obesity (waist >35 inches in women & 40 in men) Plus: hypertension & elevated blood triglyceride & low hdl levels. Insulin resistance (above normal fasting blood glucose >100 mg/dl) Higher the circulating level of cholesterol, the greater risk of death from coronary artery disease. Hdl >40 mg/dl - low cvd risk. Higher % fat calorie intake = higher risk for heart disease. Countries that have a high intake of fat tend to have an increased risk for heart disease. Recommended to keep fat intake < 25-35% of total calories. Exception: coconut oil is high in saturated fat but no essential fat. Goal: 10% or more of total calories. Omega-3s: help lower ldl cholesterol & heart disease risk. Goal: eat seafood twice weekly & include plant sources of omega- Dietary cholesterol & soluble fiber"s impact on heart disease risk. Quality protein critical for strong immune system.

Related Questions

uestions 7. In the colorimetric determination of cholesterol the enzyme cholesterol oxidase, the agent that oxidi the colorless organic compound 4-aminoantipyrine a pink complex is a. Hydrogen peroxide bÂ·Cholest-4-ene-3-one . Which of the following methods for lipoprotein elec- trophoresis depends on charge and molecular size? b. Paper c. Cellulose acetate d. Agarose d. Phenol 2. Which of the following statements concerning chylomi- crons is FALSE? a. The major lipid transported by this lipoprotein is 8. Which lipoprotein is the major carrier of cholesterol to peripheral tissue? a. LDL b. Chylomicrons c. VLDL d. HDL cholesterol. b. This lipoprotein is produced in the intestinal c. The primary function is to carry dietary (exog d. It remains at the origin (point of application) dur- mucosa enous) lipids to the liver. ing lipoprotein electrophoresis. 9. True or false? Increased levels of apo A-I are associ- ated with increased risk of CAD 3. The lipoprotein that contains the greatest amount of protein is called a. HDL 10. A patient is admitted to the hospital with intense chest pains. The patient's primary care physician requests the emergency department doctor to orde several tests, including a lipid profile with chol fractionation.Given the patient's results below, what would be the LDL-C for this patient c. VLDL d. LDL 4. True or False? Pre-beta (VLDL)-lipoproteins migrate Total cholesterol- 400 mg/dL; triglycerides further toward the anode on polyacrylamide gel than HDLC - 100 mg/di LP electrophoresis, pending they do on cellulose acetate or agarose a. 240 mg/dL b. 160 mg/dL c. 200 mg/dL d. 300 mg/dL 5. Several enzymatic triglyceride methods measure the production or consumption of a. NADH b. Fatty acids c. Glycerol d. Diacetyl lutidine 11. A patient is admitted to the hospital wit chest pains. The patient's primry requests the emergency 6. The most likely cause for serum/plasma to appear several tests, including a lipid protile fractionation. Given the patient's resu below, what would be this patient s a "milky" is the presence of LDL-Cstatus 3u b. VLDL c. LDL d. HDL Total cholesterol 400 mg/dL; HDL-C = 100 mg/dL; LP electrop a. High b. Optimal c. Desirable d. Borderline

QUESTIONS TO ANSWER:
1.Looking at Janeâs lab profile, it is indicative of what condition?
2.What are the two most common causes of this condition?
3.Which lab result is critical in the diagnosis of this disease?
4.Discuss the significance of the Hematology results?

Jane L) a 30-year-old woman, was seen in the ER with severe epigastric pain radiating to the back that woke her from sleep. She also complained of nausea and vomiting. The chemistry and hematology tests shown in Tables 2â8 and 2â9 were ordered.

Jane L. Reference Range

		Sodi um		140		135-145 mEq/L
		Potassium		3.6		3.6â5.0 mEq/L
		Chloride		106		98-107 mEq/L
		C02		29.0		24.0-34.0 mEq/L
		Glucose		116		80-120 mg/dl,
		Bilirubin, total		0.2		0.2â1.9 mg/dL
	AST ALP Protein				26 53 6.8		5-40 IU/L 30-157 IU/L 6.0-8.4 gidL
	2120				2121		Reference Range
BUN			13			7â24 mg/dL
Creatinine			1.2	1.2		0.5â1.2 mg/dL
Calcium			9.0	8.8		8.5â10.5 mg/dL
Albumin			4.2			3.5-5.0 g/dL
ALT			23	NT		5â40 IU/L
Amylase			738	265		10-110 IU/L
Lipase			3970*	320		31-186 IU/L
			335	NT		13-86 IU/L
Cholesterol			NT	165		Recommended (desirable): < 200 mg/dL
Triglyceride			NT	155		Recommended (desirable): < 250 mg/dL

2120

2121

Reference Range

WBC

RBC

ESR

12.1

4.93

10.8

4.76

5-10 x 10⁹/1.

4.0-5.0 x

0â20 mm/h

HDL 35 Recommended (desirable): 60 mg/dL LDL NT 99 Recommended (desirable): 130 mg/dL *Lipemic sample, results rechecked.

Abbreviations: ALT, alanine aminotransferase; ]GT, gamma glutamyltransferase; HDL, high-density lipoprotein; LDL, low-density lipoprotein; NT, not tested.

Table 2-9 " HEMATOLOGY

Abbreviations.' ESR, erythrocyte sedimentation rate; NT, not tested.

NUT 10 Lecture Notes - Lecture 17: Coronary Artery Disease, Monounsaturated Fat, Polyunsaturated Fat

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