NPB 168 Lecture Notes - Lecture 4: Adenylyl Cyclase, Nippon Professional Baseball, Semisynthesis
27 Apr 2016
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Neurons & signaling: neurons have different forms depending on their function, form is parallel with function, think of drug use as a form of learning. As you expose nerve cells to drugs, this may cause change in brain cell structure which can change function in your brain. Drug is interrupting the normal conversation that goes on within the nervous system. G protein made of guanine nucleotide trimer: g protein can modulate an ion channel, inside postsynaptic cell driven by second messengers where g protein is communicating with an effector enzyme to create second messengers (2nd messenger cascade) G protein affecting adenylyl cyclase -> atp -> camp -> camp-dependent protein (pro-) kinase: gs stimulates pathway, upregulates camp, gi inhibits pathway, makes less of camp. Phospholipase c -> hydrolysis of phosphoinositide molecules: activation of ip3 and dag. Ip3 -> activates ca2+ channels to increase intracellular [ca2+] -> calmodulin protein kinase. Dag -> activates pkc (protein kinase c)
