NPB 168 Lecture Notes - Lecture 5: Heroin, Active Ingredient, Analgesic
19 Jul 2019
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Narcotic (opitates only, drug that makes you sleepy) Dry goo to paste then to powder to get opiates: structure-function relationship, don"t need to memorize the structure, morphine. Acetylation of morphine to get heroin - acetyl groups. "semi synthetic: heroin is more potent than morphine and more lipid soluble, converted to morphine quickly in brain when heroin is taken, higher faster , greater addictive factor, codeine, methoxy group. Opioid - derived from naturally occurring: naloxone. Bind to receptor and inhibiting receptor (opposite of agonist) Opiate - naturally occurring: can get similar structures but different effects. And completely diff structures can have similar effects: heroin. Increase of 272% of deaths in heroin death from 2010 to2013. 4/5 heroin initiates (users) are using non-medical rx opiates 1st: forms of heroin. Not likely found because too costly to make and can easily overdose, no returning customer to buy the drug.
