NPB 168 Lecture Notes - Lecture 4: Efferent Arteriole, Afferent Arterioles, Breast Milk
19 Jul 2019
School
Department
Course
Professor
Document Summary
Processing blood in kidney: input, blood, enters afferent arteriole and into glomerulus, surrounded by bowman"s capsule and exits through the efferent arteriole, 20% of plasma that enters the glomerulus is filtered, 80% is. The cells might be releasing some metabolic enzyme that will break the drug down: primary metabolic site- most of drug is broken down, depot binding drug in systemic blood supply binds to depot sites. Keeps it from binding to the active sites. Extracellular loops that interact with drugs (ligands: alpha helical regions, work by interacting with g proteins. 5: ionotropic, make ion pore, that charged molecule can go through. No effect!: neuronal responses to metabolic receptor binding, 1st messenger: drug itself, second messenger, 3rd messenger, dose response curve, threshold dose, dose that yields the first measure able affect, maximum response, efficacy of drug, sigmoidal shape. Can get an effective dose without getting too close to the lethal dose.
