NPB 168 Lecture Notes - Lecture 8: Tachycardia, Sympathetic Nervous System, Oxidative Stress
19 Jul 2019
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Lec 8: acute effects of cocaine, physiological (sympatheomimetic, attention, movement (psychomotor, toxic effects of cocaine use, cardiovascular consequences of cocaine, sympathetic nervous system. Increased heart rate, blood pressure, contractility: heart is beating harder and faster, making tissue in heart more metabolically active. Increased myocardial oxygen demand: cardiomyoctes, blockade of sodium and potassium channels depresses cardiovascular parameters, voltage gated channels. Interference with calsequestrin-mediated calciumstorage and release disrupts excitation-contraction coupling: keeps heart beating over and over again, progressive oxidative stress causes mitochondrial damage and cell death, oxidative stress is a damaging problem to cell. Happening in muscle of heart: vasculature, vasoconstriction and prothrombiotic state, vasoconstriction cocaine makes the vessel tubes smaller. Organs and cells downstream of the area lack nutrients from the blood. Blood flooding tissue is toxic to tissue: ischemic stroke doesn"t cause explosion. Cells downstream don"t receive proper nutrients, and won"t work properly. Can cause heart attack: arrhythmias, pattern of heart beat not normal, seizure.
