NPB 110 Lecture Notes - Lecture 10: Renal Corpuscle, Renal Physiology, Capillary Pressure

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Glomerular filtration : production of cell- free , somewhat protein - free filtrate occurs at the renal corpuscle. Tubular secretion : movement from blood to nephron. Tubular reabsorption : movement from nephron back to blood ( major process ~ 991 . filtrate reabsorbed ) Production of filtrate by the renal corpuscle. Filtrate has nearly same composition as plasma except filtrate nearly protein free. Create 125ml filtrate from blood 1 minute " 18011 day. Method to create lots of filtrate then reabsorb lots. 20 -l . of plasma in renal flow filtered. " cap111am endothelium : wall of glomerular capillaries , fenestrated with pores. Basement membrane : cons113 of negatively charged glycoproteins. Pod 0 lutes : located on bowman "s capsule visceral. Restricts exchange based on size and charge layer. Small molecules , 10ns , water easily pass na bulk flow. Glomerular capillary pressure ( poc) : largest driving force. Much higher than systemic animal pressure 155 - 60 mmhg)

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