MIC 102 Lecture Notes - Lecture 6: Multiprotein Complex, Succinic Acid, Glycolysis
16 Oct 2017
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Document Summary
Building blocks typically make up macromolecules polymer: nucleotides -> nucleic acids, amino acids -> proteins. If a microbe cannot make one of these, it must acquire it from the environment. Tradeoff between making your own or getting from the environment: cost to the cell, limitations, less energy expenditure. How to make building blocks & precursor metabolites. Steps: entry into cell, feeder pathways, central pathways. Diffusion: porins allow free diffusion of water and hydrophobic solutes below 7000 daltons, sugar, amino acids and most ions. Facilitated diffusion: diffusion through more specific porins that recognize solute. Energy coupled transport: specialized porin complexes with inner membrane proteins to use atp energy to actively transport the solute across. Gram negative cell through periplasm (space between inner and outer. Simple diffusion not useful for much. Facilitated diffusion selective protein channels: rare in prokaryotes. Passive transport uses concentration gradient no energy input.
