21.16 Consider the dimerization 2 AA with forward rate constant k, and reverse rate constant k. (a) Derive the following expression for the relaxation time in terms of the total concentration of protein, l tot-AI + 2A, (b) Describe the computational procedures that lead to the determination of the rate constants k, and k' from measurements of Ï for different values of Alot (c) Use the data provided below and the procedure you outlined in part (b) to calculate the rate constants k, and k, and the equilibrium constant K for formation of hydrogen-bonded dimers of 2-pyridone: [P]/(mol dm-*) 0.500 0.352 0.251 0.151 0.101 t/ns 2.3 2.73.3 4.0 5.3
Show transcribed image text 21.16 Consider the dimerization 2 AA with forward rate constant k, and reverse rate constant k. (a) Derive the following expression for the relaxation time in terms of the total concentration of protein, l tot-AI + 2A, (b) Describe the computational procedures that lead to the determination of the rate constants k, and k' from measurements of Ï for different values of Alot (c) Use the data provided below and the procedure you outlined in part (b) to calculate the rate constants k, and k, and the equilibrium constant K for formation of hydrogen-bonded dimers of 2-pyridone: [P]/(mol dm-*) 0.500 0.352 0.251 0.151 0.101 t/ns 2.3 2.73.3 4.0 5.3