BIS 102 Lecture Notes - Lecture 14: Acid Dissociation Constant, Histidine, Weak Base
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Increases pka becomes better base to pick up ht. Tissues ph 7. 2 oxy hb - deoxy hb. + to ph =pkat 109 b la: 6=6. 21-109 bla bla - Charges too far away ( r is too lame) according to. " from oxy hb ( pka 6. 2) to deoxy hb (pka 7. 7) 32x increase in bas auth to bind ht. 1 ( 7. 7 ) ph =pkat 109 bla. Increase in pka of histidine contributes to formation of salt bridge. If ph did not change (same as within lunas ) : P kat 109 b la ph - I 11. 791=561 . therefore increase in ht makes salt bridge about 201 . stronger. 10 4 hb deoxy hb) positive and negative charges brought closer together. " t thermodynamically favored because can form weak ionic bond with - Pka increases to become better weak base to bind ht to achieve positive charge. It positive charge moves into nonpolar interior.
