BIOL 1013 Lecture Notes - Lecture 7: Adaptive Immune System, Cytotoxic T Cell, Clonal Deletion
Document Summary
White blood cells participate in both innate defenses and adaptive immunity. Natural killer cells- lymphocytes destroy cancerous or virally infected cells. Cytokines- interferons sound the alarm secretes and binds to another cell that prepare other cells. Wbcs that eat single celled organisms?- monocytes and neutrophils. Wbcs that induce inflammation- basophils (closely related- mast cells) Instance where pricked or stabbed- basophils released histamine, which dilates blood vessels, thus recruiting more wbcs. Histamine makes vessels more permeable- platelettes and wbcs go to wound site and wbcs destroy invaders. Antigens in cell membrane act as name tags. Lymphocytes- b cells, t cells(adaptive immune response), natural killer cells (innate defense) Autoimmune disease- lymphocytes fail to recognize friendly antigens. Mhc (major histocompatibility complex) cell surface proteins essential for acquired immunity: auto-recognition, antigen presenting chaperones. Adaptive immune responses- b cells long distance killers (antibodies) Nk cells cannot target specific antigens (innate defense)
