BMB 420 Lecture Notes - Lecture 2: Urease, Reactive Nitrogen Species, Lewis Antigen System
8 Feb 2018
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Lophotrichous flagella: move to epithelium (mucus layer) Adhere factors: baba and saba bind to lewis blood group antigens. Phase variation: turning on or off of surface antigens. Vaca (vacuating cytotoxin a): disrupts polarity of cells. Apical: inner lining of stomach: pylori wants to disrupt basal vs apical so what goes in and out of stomach is disrupted. Blood is able to travel into the stomach. Tight junctions are the space between cells in a tissue. If they are disrupted, things can easily pass through the tissue. In this case, stomach acid is able to damage the stomach as the mucus layer is no longer solid and cause ulcers due to erosion. will allow pathogens to acquire iron from host cells. Effector mechanism: deposited directed into host cells to cause an effect. In this case, to acquire iron from host. Molecular mimicry: modification of bacterial antigens to look like host proteins. (example, gonorrhea).
