BMB 300 Lecture Notes - Lecture 30: Complement Membrane Attack Complex, Mast Cell, Antitoxin

• School: University of Maine
• Department: Micro and Molecular Biology
• Course: BMB 300
• Professor: Edward Bernard

Document Summary

Precipitation: igm has 10 binding sites. allows antigens and antibodies to form an insoluble clumps. Agglutination: crosslink large groups of cells together and make a large insoluble antibody cluster so it can be recognized by phagocytes. Compliment fixation: facilitate complimentary proteins to activate compliment pathway. Can only work if the toxin hasn"t taken effect yet. Activated protein will cleave the next in the line. C3 a/b whether or not it is cleaved. All have the same end goal: membrane attack complex. (mac). Mac: form a pore in outer membrane in gram neg. bacteria. Fluid will enter and cause cell to burst and die. kills gram (-) bacteria. Bystander effect: all eukaryotic cells in the vicinity are at risk. Antibodies can"t clear viruses as they cannot enter the cell where viruses are found. Need cell- mediated immunity, are able to cause apoptosis. Cannot have cell mediated immunity without also having humoral immunity.