BMB 208 Lecture Notes - Lecture 17: Atp Hydrolysis, Pyruvic Acid, Glycolysis
2 Jan 2018
School
Department
Course
Professor
Document Summary
Gross anatomy of glycolysis: preparatory phase- invest 1 glucose, invest 2 atp, cleave chain, occurs in the soluble cytoplasm of the cell, payoff phase- oxidize carbon, get 4 atp (2 net), get 2 nadh, 2 pyruvate. Activators of phosphofructokinase i: amp and adp are products of atp hydrolysis. Allosteric inhibitors of pyruvate kinase: high atp decreases af nity of enzyme for substrate phosphoenolypyruvate and slows reaction- slows glycolysis tranferase activity. Glycogen breakdown near a alpha1-6 branch point- catalyzed by the debranching enzyme: activities of the deb ranching enzyme. Cascade response to hormonal activation: speci c hormones: epinephrine in muscle glucagon in liver, hormonal signal- ght or ight response, sequential signal ampli cation causes large and fast response, many camp dependent systems in cell respond in similar way.
