PSIO 303A Lecture Notes - Lecture 5: Receptor Tyrosine Kinase, Heterotrimeric G Protein, Signal Transduction
1 Sep 2016
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Document Summary
Lecture 4 and 5 - second messenger systems - part 1. Signal transduction as a fundamental mechanism of cell to cell communication and modulation of the functionality of the target cell. General mechanism by which plasma membrane receptors initiate signaling event in a cell and how functionality of an intercellular protein can be modified by a change in phosphorylation. Signal amplification: large cellular event can be induced by a small initial extracellular signal. List and understand the four types of cellular receptors. Describe the mechanisms of the three categories of plasma membrane receptors. Direct cell-cell transfer of factors via pores (e. g. connexins) Endocrine, paracrine, and autocrine process (chemicals are released by nearby cells or same cell) of chemical messenger. Release interstitial fluid (in bloodstream) and are picked up by other target cells. Cells that release signaling molecules (paracrines), in interstitial fluid (no contact with blood stream) and picked up by target cells.
