PSY 351LEC Lecture Notes - Lecture 10: Opioid Receptor, Cannabinoid Receptor, Partial Agonist
22 May 2019
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Psychopharmacology: study exogenous drugs on nervous system. Some time receptor cause excitatory response sometimes inhibitory response. Pure antagonist does not work on its own unless agonist is there. Direct antagonist binds to and blocks neurotransmitter receptors,and prevent neurotransmitter themselves from attaching to the receptors indirect agonist increases and enhances the amount of neurotransmitters affected, but has no specific agonist activity at the receptor. Gaba: when open gaba channel we inhibit the cell,major inhibitory neurotransmitter in the central nervous system (non competitive binding) Benzodiazepines: a drug enhance the effect of the gaba at the gabaa receptor, resulting in sedative, hypnotic (sleep-inducing), anxiolytic (anti-anxiety), Barbiturates : drugs that reduce anxiety and depress central nervous system activity. Anandamide: a neurotransmitter first natural ligand for thc, allows the body to recognize thc and to alter normal brain communication. Cannabinoid receptors are concentrated in certain areas of the brain associated with thinking, memory, pleasure, coordination and time perception.
