CH 461 Lecture Notes - Lecture 25: Carbamoyl Phosphate Synthetase, Carbamoyl Phosphate, Pyrimidine Metabolism
Document Summary
Although both pyrimidines and purines are components in nucleic acids, they are made in different ways. Likewise, the products of pyrimidine degradation are more water soluble than are the products of purine degradation. Unlike in purine biosynthesis, the pyrimidine ring is synthesized before it is conjugated to prpp. The second reaction is ring closure to form dihydroorotic acid by the enzyme carbons located in the same positions as in the mature pyrimidine ring. carbamoylaspartate. The carbamoyl phosphate synthetase used in pyrimidine biosynthesis is located in the cytoplasm, in contrast to the carbamoyl phosphate used in urea synthesis, which is made in the mitochondrion. The enzyme that carries out the reaction is aspartate transcarbamoylase, an enzyme that is closely regulated. The first reaction is the conjugation of carbamoyl phosphate and aspartate to make n dihydroorotase. This circular product contains a 6 membered ring with nitrogen and. The third reaction is the oxidation of the ring to form a carbon carbon bond.
