BSC 450 Lecture Notes - Lecture 3: Deprotonation, Methionine, Zwitterion
11 Sep 2017
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Document Summary
Biological buffer systems: maintenance of intracellular ph is vital to all cells, enzyme catalyzed reactions have optimal ph, solubility of polar molecules depends on h-bond donors and acceptors, equilibrium between co2(g) and dissolved hco3. Depends on ph: buffer systems in vivo are mainly based on, phosphate, concentration in millimolar range, bicarbonate, important for blood plasma, histidine, efficient buffer at neutral ph. Amino acids building blocks: 20 common amino acids to build proteins, - amino acids. Amino acids share many features, differing only at the r substituents. Most -amino acids are chiral: the -carbon always have four substituents and is tetrahedral, all have, acidic carbonyl group, basic amino group, hydrogen connected to ca, fourth substituent (r) is unique (except gly, only l-configuration exists in proteins. Amino acid: classification: common amino acids can be places in 5 basic groups depending on r substituents, nonpolar, aliphatic, aromatic, negatively charged, polar, uncharged, positively charged.
