BSC 315 Lecture Notes - Lecture 14: Microbiological Culture, Catabolism, Human Body
Document Summary
Loss of function- allele that produces a product w/ reduced function. Most completely recessive mutant alleles encountered to date are of this type (cid:1) (cid:1) (cid:1) Haploinsufficiency (close to incomplete dominance)- normal function requires about 100% activity. Loss of one copy in heterozygotes produces a mutant phenotype (cid:1) Gain of function alleles- mutation causes extra/inappropriate activity. Hypermorphic- too much activity: most often in negative cellular regulators, mutation results in the failure to turn off. Neumorphic- mutation results in a new function, or function in an inappropriate location/stage. Antimorphic- mutant protein poisons normal proteins: most often multimeric proteins (>1 subunit) (cid:1) (cid:1) (cid:1) (cid:1) Some fungi (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) Human body carries about 1013 living bacterial cells. 10x more bacterial cells than human now in dispute. Bacteria & unicellular eukaryotes are grown in liquid culture or on agar (semi-solid) plates. Studied by testing growth in defined media.