BSC 300 Lecture Notes - Lecture 25: Sic1, Syntelic, Synapsis
18 Apr 2018
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Separase protease activity is inhibited by cdk phosphorylation and securin binding: when spindle checkpoint controls indicate all kinetochores are attached to microtubules and the spindle is properly assembled and oriented, the cdc20 specificity factor directs the. Induce dna repair machinery: cause cell cycle arrest by inhibiting cdc25. In metazoan cells, activate the tumor suppressor transcription factor p53, which: Induces cell cycle arrest by activating transcription of the cki p21: or when dna damage is severe, activates apoptosis, dna damage stimulates the p53-p21 pathway to inhibit g1 and mitotic cdks, atm or atr (atm/r) protein kinases: Stimulate chk1/2 protein kinases to inhibit cdc25, which blocks s phase and mitotic. In the first division, homologous chromosomes pair and then segregate ensuring that daughter cells receive a full haploid set of chromosomes. In the second division, the two chromatids are separated: the stages of meiosis, dna is replicated prior to meiosis, prophase i consists of several stages:
