BSC 300 Lecture Notes - Lecture 12: Succinic Acid, Dehydrogenation, Adipocyte
28 Sep 2016
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Describe the inner/outer mitochondrial membranes and matrix. Describe the function of the tricarboxylic acid cycle- input/export. Emphasize electron transport system in forming a proton gradient. Describe the chemiosmotic mechanism and cellular energy transduction. Clarify mechanisms for transporting protons to the intermembrane space. The function of atp synthase in atp synthesis. Early earth was populated by anaerobes, organisms that capture and utilize energy by oxygen-independent metabolism. Oxygen accumulated in the primitive atmosphere after cyanobacteria appeared. Aerobes evolved to use oxygen in order to extract more energy from organic molecules. In eukaryotes, aerobic respiration takes place in the mitochondria. Outer mitochondrial membrane: similar in lipid composition to eukaryotic plasma membrane. Integral membrane proteins called porins allow metabolites, ions and small proteins to freely diffuse into the intermembrane space. Large proteins require specific translocation signals for active transport into the intermembrane space. Inner mitochondrial membrane: lipid composition more similar to prokaryotic membrane.
