BSC 215 Lecture Notes - Lecture 13: Epiphyseal Plate, Intramembranous Ossification, Endochondral Ossification

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Bone Development
The skeleton arises from fibrous membranes and hyaline cartilage during the first month of
embryonic development. These tissues are replaced with bone by two different bonebuilding, or
ossification, processes.
The first process, called intramembranous ossification, occurs when fibrous
membranes are replaced by bone tissue. The process, occurring only in
certain flat bones, such as the flat bones of the skull, sternum, and clavicle,
is summarized in two basic steps:
1. Spongy bone tissue begins to develop at sites within the membranes
called centers of ossification.
2. Red bone marrow forms within the spongy bone tissue, followed by the formation of
compact bone on the outside.
The second ossification process, called endochondral ossification, occurs
when hyaline cartilage is replaced by bone tissue. The process, occurring in
most bones of the body, follows these steps:
1. At a primary ossification center, in the center of a cartilage model,
hyaline cartilage breaks down, forming a cavity.
2. A periosteal bud, consisting of osteoblasts, osteoclasts, red marrow, nerves, and
blood and lymph vessels, invades the cavity. The osteoblasts produce spongy bone
tissue.
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