BIOL 221 Lecture Notes - Lecture 6: Distal Convoluted Tubule, Proximal Tubule, Macula Densa

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6 Mar 2020

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Macula densa: dct where it begins (and nephron loop ends, osmoreceptors respond to changes in osmolality of filtrate, secrete vasoconstrictor. The macula densa cells of the dct are located where it begins (and the nephron loop ends). They serve as osmoreceptors monitoring and responding to changes in the osmolality (solute concentration) of the filtrate. (osmolality is based on the ratio of the mass of solute to the mass of the solvent and gives a good idea of the effect of solute concentration on osmosis. The higher the osmolality, the more the solution will cause osmosis. ) The macula densa cells secrete a local vasoconstrictor that acts on afferent arterioles to decrease flow into glomerulus when solute concentration in filtrate is high. Distal convoluted tubules (dct: simple cuboidal epithelium (fewer microvilli than pct, absorption & secretion, principal cells, respond to hormones (adh, aldosterone, intercalated cells, respond to ph.

Related Questions

1) A drop of urine would follow this path

a) renal pyramid/major calyx/minor calyx/renal pelvis/ureter

b) minor calyx/major calyx/renal pyramid/renal pelvis/ureter

c) renal pelvis/minor calyx/major calyx/renal pyramid/ureter

d) renal pyramid/minor calyx/major calyx/renal pelvis/ureter

2) The production of filtrate starts at

a) Loop of Henle

b) capsular space

c) distal convoluted tubule

d) proximal convoluted tubule

3) Major reabsorption of water happens by ____at the _____

a) contransport, distal convoluted tubules

b) Cl- shift, nephron loop

c) countercurrent, nephron loop

d) countercurrent, ureter

4) Angiotensin II causes production of ____to increase Na + reabsorption in the _________

a) renin; collecting duct

b) aldosterone; PCT

c) ADH; nephron loop

d) aldosterone; collecting duct

5) Most of the reabsorbed compounds from the filtrate end up in the

a) peritubular capillary

b) urine

c) nephron loop

d) DCT

6) Reabsorption of urea happens by

a) transcellular movement

b) by paracellular movement

c) by cotransport with glucose

d) by HCO3- movement

7) Transport Maximum, in urinary system terms, refers to

a) proteins performing âtransportâ out of the filtrate at maximum rate

b) the reason why a diabetic produces large volumes of diluted urine

c) excess filtrate components being urinated out of the body

d) All choices are correct

8) Urine does not drop below pH 4.5 because

a) proteins that move H+ into filtrate stop working when too much H+ builds up in filtrate

b) proteins in urine neutralize acid

c) H+ are always buffered

d) the buffering system in urine does not run out

9) Hyperkalemia will

a) activate adrenal cells to secrete aldosterone

b) can stop the heart

c) No choices are correct

d) cause reduced excitability of neurons

e) All choices are correct

10)In your body, chloride (Cl-) can be found in its highest concentration in

a) extracellular fluid

b) intracellular fluid

c) Neither choice is correct

11) Diuretic abuse leads to

a) All choices are correct

b) two choices are correct

c) No choice is correct

d) dehydration

e) athletes being accused of doping

f) hypotonic hydration

12) Long diffusion distance, low blood pressure, and impaired circulation are the result of

a) hypernatremia

b) edema

c) hyperkalemia

d) water toxicity

13) In males FSH is under feedback control by _____ and is down regulated when _________reaches high concentrations

a) inhibin, testosterone/sperm #s

b) testosterone, inhibin/sustentocyte #s

c) ADH, inhibin/sustentocyte #s

d) LH, testosterone/sperm #s

14) Testosterone production is done by ____-cells

a) posterior pituitary

b ) interstitial endocrine

c) anterior pituitary

d) sustentocytes

15) Upon _____of estrogen/progesterone, the ____phase of the uterine cycle begins

a) increase; menstrual

b) decrease; menstrual

c) increase; proliferative

d) decrease; secretory

16) Progesterone

a) All choices are correct

b) is low in the luteal phase

c) No choices are correct

d) raises in the follicular phase

e) is high along with estrogen during the follicular phase

17) Which nephron is most responsible for urine concentration?

a) cortical nephrons

b) Juxtamedullary nephrons

c) Neither

carminesalmon877

1) Which of the following is a component of a vertebrate kidney? (Select all correct choices.)

		glomerulus
		Bowman's capsule
		renal tubules
		collecting ducts
		Malphigian tubules

In organisms, the ability to control osmosis depends on the properties of the plasma membranes of individual cells. Based on their ability to permit the free movement of water and some solutes, these membranes are best described as: (select all correct choices)

		impermeable.
		permeable.
		semipermeable.
		diffusible.
		impervious.

3)I selected cortex; inner medulla, it was wrong.

The loops of Henle create a concentration gradient in the interstitial fluid surrounding the loop, with the concentration highest in the ____________ and lowest in the ____________ of the kidney.

		inner medulla; cortex
		outer medulla; inner medulla
		outer medulla; cortex
		cortex; inner medulla
		cortex; outer medulla

The main solutes in the filtrate as it enters the distal convoluted tubule are: (select all correct choices)

		urea.
		electrolytes.
		other wastes.
		amino acids.
		nucleotides.

5) Ensure all correct choices are selected, for this question I only selected osmosis and it was wrong,

Water moves by: (select all correct choices)

		random molecular motion.
		active transport.
		passive transport.
		osmosis.
		facilitated diffusion

Compared to sexual reproduction, asexual reproduction: (select all correct choices)

	requires less investment in attracting mates.
	allows much more rapid population growth.
	is rarely found as the sole mechanism of reproduction.
	results in the production of genetically identical cells or individuals.
	involves meiosis and fertilization as core processes.

A key difference between hormonal regulation of the reproductive systems of males and females is that:

	LH and FSH are released only in females.
	LH and FSH are released only in males.
	LH and FSH are released cyclically in females but nearly continuously in males.
	LH is released in males and FSH is released in females.
	LH is released continuously in males and FSH is released cyclically in females.

True or false: In response to LH and FSH, ovaries secrete estrogen and progesterone.

	true
	false

During the luteal phase of the menstrual cycle, if the oocyte is not fertilized, a number of events occur which are listed below. Select the answer that places the events in the correct chronological order.

Events:
1. the lining of the uterus is shed
2. the corpus luteum secretes progesterone
3. follicle cells are converted to the corpus luteum
4. the corpus luteum degenerates
5. estrogen and progesterone levels fall

	3, 2, 4, 5, 1
	1, 2, 3, 4, 5
	2, 4, 3, 1, 5
	4, 3, 2, 1, 5
	5, 2, 3, 4, 1

10)

If an antibody is missing its Fc fragment, what would happen if this antibody encounters its target antigen in the bloodstream? Select all correct choices.

	The antibody would be able to bind the antigen at a specific epitope.
	The antibody would be able to bind the antigen, but not at an epitope site.
	The antibody would not be able to bind to the antigen.
	The antibody would be able to activate components of the complement system.
	The antibody would not be able to activate components of the complement system.

11)

If an individual carries a mutation that results in a complete lack of MHC class I proteins, how would the individualâs immune response be affected? Select all correct choices.

	Memory cell antibodies would not be able to attach to antigen epitopes.
	Cytotoxic T cells would not be able to target (and destroy) infected cells.
	Helper T cells would not be able to interact with antigen-presenting cells.
	Plasma cell antibodies would not be able to attach to antigen epitopes.

12)

Which of the following statements is true regarding T cell receptors? Select all correct choices.

	They recognize antigen-MHC complexes.
	They contain variable and constant regions.
	They are composed of two heavy (H) chains and two light (L) chains.
	They are formed by the rearrangement of V, J, C, and D gene segments.
	They can be found in the bloodstream independent of T cells.

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BIOL 221 Lecture Notes - Lecture 6: Distal Convoluted Tubule, Proximal Tubule, Macula Densa

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