BIOL 221 Lecture Notes - Lecture 7: Peripheral Chemoreceptors, Ketone Bodies, Sigmoid Function
3 Mar 2020
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Metabolically-derived acids (lactic acid, keto-acids & others) Decreased arterial ph stimulates peripheral receptors increased ventilation even if pco2 and po2 are normal. Normal arterial ph average around 7. 4; the normal range is 7. 35 to. The addition of acids (increased hydrogen ion content) lowers the ph and stimulates peripheral chemoreceptors. Added acids include carbonic acid formed from reaction of carbon dioxide with water and metabolically-derived acids (e. g. , lactic acid, keto-acids, and ketone bodies). These acids lower ph and stimulate peripheral chemoreceptors leading to increased ventilation even if arterial carbon dioxide and oxygen levels are normal. Increased ph from decreased hydrogen ion levels stimulates the receptors less leading to a decrease in depth and rate of breathing. Po2 of normal systemic arterial blood ~ 100 mm hg. Oxygen-hemoglobin dissociation curve receptors only stimulated when. Systemic arterial oxygen levels (partial pressure of oxygen; po2) is the least important of the three factors.
