NSG 3315 Lecture Notes - Lecture 45: Collagen, Rankl, Osteoblast
Document Summary
They control bone remodeling by: laying down new bone secreting a compound (rank ligand) that controls the osteoclasts, the bone breaking cells. Normally bone formation and breakdown are balanced to replace damaged bone maintain the amount an d density of bone. Bone cells and bone marrow cells produce opg osteoclasts are told not to function bone breakdown decreased bone grows. Vitamin c and d are necessary for formation. Mechanical stress - stimulates osteoblast activities and stimulates formation of matrix. Calcitonin - keeps calcium and phosphate in cell; stimulates bone growth. Osteopenia - decreased bone; not diagnosis by condition. Osteoporosis - decreased bone mass; increase risk of breaks or fractures decreased cancellous (spongy) bone strength occurs more in older women; decrease in estrogen levels bone breaking < bone formation. It result sin: bone pain and tenderness fractures deformities. May have stunted growth, delayed teeth growth, soft spots don"t close as quickly, larger softer skull.
