NSG 3301 Lecture Notes - Lecture 54: Saquinavir, Daptomycin, Clindamycin
Document Summary
Pathogen microbes (unicellular or small multicellular organism) that are capable of producing a disease. Drugs used to treat infection can be classi ed according to the type of microbe. Fungus - antifungal (worms) helminth - antihelminithic, antiparasitic. Inhibition of nucleic acid synthesis - inhibit enzyme. Bacteriostatic - slow growth of micro-organism, but immune system responsible for destroy bacteria. Ability to suppress or kill infecting microbes without injury to the host. Achievable because drug accumulates in a microbe at higher levels than humas, and the speci c action is unique or more harmful to certain microbes. Most common location of resistant bacteria > hospitals. Conjugation - sexual reproduction when two microbes join to transfer genetic material. Drug concentrations in tissues that are too low to kill resistant organisms contribute to the development of resistance. Minimum inhibitor concentration of a drug must be present to slow or stop the replication of the microbe.
