BIOL 4376 Lecture Notes - Lecture 44: Leukotriene, Phospholipid, Bone Resorption

• School: Temple University
• Department: Biology
• Course: BIOL 4376
• Professor: Allen Nicholson

Document Summary

Thromboxane can increase platelet aggregation whereas prostacyclin is decreasing. Where eicosanoids are synthesized and where they act are cell dependent. Thromboxane a2 has action to promote platelet aggregation (procoagulation response), as well as smooth muscle constriction. Endothelial cells make prostacyclin pgi2, inhibiting platelet aggregation and promoting smooth muscle vasodilation. The uterus makes prostaglandin pgf2 alpha that causes uterine smooth muscle contraction. Pge2 is produced and effects body temperature, inflammation and bone resorption. Modulates kidney cell vasodilation: very important in loop diuretics, however if a patient is taking an nsaid as well, it"s contraindicated because nsaids inhibit the production of pge2. Eicosanoids, thromboxanes, prostaglandins are involved in many physiological roles; all over the place in terms of physiology. Leukotrienes promote bronchodilation of the airway smooth muscle. In the stomach, there"s inhibition of gastric acid secretion. Synthesized by cleavage of phospholipids from the membrane. Phospholipase a2 cleaves phospholipids from the membrane to .