BIOL 3327 Lecture Notes - Lecture 41: Enalaprilat, Lisinopril, Ramipril
15 Jul 2020
School
Department
Course
Professor
Document Summary
When they"re both taken, the nsaid enhances the reduction in gfr, which can lead to a dangerous reduction in gfr resulting in renal failure. Important to note which are prodrugs and which are renally eliminated. Any kind of renal insufficiency will mean the drugs eliminated by the kidney will hand around longer. All aceis have essentially the same moa and similar efficacy in treatment of heart failure and hypertension. Block ability of angiotensin ii to bind to and activate angiotensin ii (at1) receptors. Drugs are competitive antagonists at at1 receptor. Pharmacologic effects similar to ace inhibitors except. Better adverse side effect profile (less coughing in patients because bradykinin and levels are not affected: less angioedema) Has no effect on bradykinin metabolism because ace is not inhibited. Clinical trials show no evidence of bradykinin-mediated side effects like coughing, angioedema, rash, etc. Best results seen when given in combination with hctz)
