VTPP 423 Lecture 28: Cystic Fibrosis
16 May 2020
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Accumulation of mucus sinus lungs affects intestines reproductive organs. Malfunction of cftr channel u mutations in cftr gene cf g cb_d is open allows cl0 down gradient in lungs skin sweat pancreas end up remodeling airway infertility in 09 still needs atp to phosphorylate and open klose. Enac makes sure nato goes in teterotrimeric g protein bends to ligand. Phosphorylation of cftr of gtp ends signal one is closed is derived from htg protein hotera keeps hta always on m keeps cftr always on makes pka nonstop excessive secretion of h2o. Class i c nonsense class 11 of508 causes substitution that causes sticky tunable to fold a fob escape and make degraded by proteosome it to being a channel. Iass ill gssid makes it hard to open iclose. Altered electrochemical balance of cftr enac 999 absence. Nato hyperabsorption u generate more mucus test gold standard weat measure cp of sweat defective cftr causes.
