VTPP 423 Lecture Notes - Lecture 27: Rheumatoid Arthritis, Thymidine Monophosphate, Dihydrofolic Acid
16 May 2020
School
Department
Course
Professor
Document Summary
Powered by folate cycle tetrahydrofolate dihydrofolate thymidylatesynthase methotrexate 5 fluorouracil 4 hydroxyurea block thymidine synthesis most effective sphase dump dtmp ribonucleotidereductase to hydroxyurea. Hydroxyurea acutegchronic leukemia trueno occlusive crises in sicklecellanemia. 5fdumpstops de novo synth of thymid synth can cause diarrhea photosensitivity is hyperpigmentation rxns myelosuppression a increased risk of infection dihydrofolate reductase. 1 irreversible methotrexate death of all rapidly dividing cells u abortions nearly unruptured ectopic pregnancy ninvasive molar preg npsoriasis rheumatoid arthritis immunosuppressivetherapy sideeffects infolate def megaloblastic anemia u dosedep. myosup. I restrict lung disease dilated bronchiole hepatotoxicity monitor lft u alopecia is mucositis stomatitis leucovorinureverses toxic mtx effects folinic acid. 6 mercaptopurine isactivated by hypoxanthinephosphoribosyl transferase hgprt us phase specific dna synth treat all acute lymphoblastic leukemia n immunosuppressive therapy. Side effect myelosuppression leucopenia tinfections pancreatitis hepatotoxicity u inactivated by xanthine oxidase. Toxic myelosuppression u hemorrhagic cystitis prevent by thydration g mesna. T risk of bladder cancer u hyponatremia 1stadh is.
