PSY 395 Lecture Notes - Lecture 17: Reuptake, Psy, Fentanyl
Document Summary
Psychoactive drugs most commonly associated with abuse and dependence: opiates, stimulants, anti-anxiety drugs, pain medications, hallucinogens. Drugs on synaptic transmission: drugs have structures similar to neurotransmitters, same chemical structure=same effect, not broken down=stays longer=effect stronger. Inhibitory drugs: mimic inhibitory nts, block excitatory nts, excitatory drugs, block re-uptake pumps for nts, mimic excitatory nts, block inhibitory nts. Immediate effects: alleviation of physical pain, relaxation, alleviation of anxiety and tension. Long-term effects: physiological craving for drug, withdrawal symptoms, gradual deterioration of health. Causal factors in opiate abuse and dependence: pleasure: primary reason for beginning opiate use, curiosity, peer pressure, stress relief. Bind to opiate receptors: heroin plugs in, replacing natural endorphins. Dopamine theory of addiction: addiction is dysfunction of dopamine reward pathway. Reward deficiency syndrome: addiction result of genetic deviations in reward pathway. Comorbidities: 50% have other forms of substance abuse, 36% have a history of trauma, depression, anxiety.
