30:718:409 Lecture Notes - Lecture 35: Ghb Receptor, Sulfoxide, Sodium Oxybate
10 Jan 2019
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Affects the carotid chemoreceptors, which can simulate restoration of bp. Also affects the respiratory center in the medulla. Moa unclear: agonist at ghb receptor (stimulation), but also act on gaba-b recpetors (sedation) No phenol, so lipophilic (absorbed across bbb to act as stimulants) S-am is 10x stimulant than r-am alpha-methyl inhibits deamination (longer doa) Just phenethylamine would form an unstable carbanolamine intermediate, leading to deamination. Alpha dimethyl is amazingcannot oxidize at all (not shown here) These compounds resemble norepinephrine (and also dopamine and seratonin) and can trigger some of the responses that these catecholamines do. Serotonin, 5-ht (5-hydroxytryptamine) to these drugs are structurally similar. While the peripherally-acting sympathomimetics ( - phenethylamines) small structural changes which make them more resistant to metabolism and better able to cross the blood-brain barrier (bbb) give them selectivity for the central sympathomimetic systems. Sympathetic nervous system - act on adrenergic systems. These drugs are used for add and adhd.
