30:718:409 Lecture Notes - Lecture 19: Calcium Channel Blocker, Nadolol, Nebivolol

• School: Rutgers University
• Department: Pharmacology and Toxicology
• Course: 30:718:409
• Professor: Dr. Lavoie and Dr. Chakalamanil

Document Summary

Propranolol, nadolol , atenolol, metoprolol, bisoprolol, nebivolol, acebutolol. Structures for most have been previously outlined in adrenergic antagonists. Beta-stimulation increases camp camp inhibits entry of ca. This process is blocked by bb, so vasoconstriction. In heart, beta-stim increases camp camp increase ca entry. Bb inhibits this process and causes relaxation to reduce strain on heart. Ca binds to form ca-troponin complex so contraction not inhibited. Pain in the heart with insufficient bf with increased o2 demand. There are three major classes of antianginal agents. These are: -antagonists or -blockers, organic nitrates, calcium antagonists or calcium channel blockers. Angina pectoris occurs as a result of coronary blood flow insufficiency (myocardial ischemia) in the face of increased oxygen demand. The principal goal in the prevention and relief of angina is to limit the oxygen requirement of the heart so that the amount of blood supplied by the stenosed or. Variant angina- transient spasm of coronary blood vessels.