30:718:409 Lecture 23: Antiarrhythmic Agents ver 1.0 Sakai 2018

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peachtiger667

27 Dec 2018

School

Rutgers University

Department

Pharmacology and Toxicology

Course

30:718:409

Professor

Dr. Lavoie and Dr. Chakalamanil

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Document Summary

Non-dhp ccb: disorder of impulse formation, disturbance in the conduction of the impulse, a combination of 1 and 2. Goal is to desensitize the heart and make it less stimulateable: to alter the electrophysiologic mechanisms causing arrhythmias, to act on the autonomic nerves to the heart, and, to inhibit the cardiac muscle (inhibitors of na+, k+-atpase system). Cardiac arrhythmias caused by: mechanism of arrhythmias. Isolated from chinchinoa tree (where we get quinine from as antimalarial) Difference from quinine is the stereoisomers at c-oh and the c at the ring connected to it. Oral quinine is always more effective at that than oral quinidine. Works on ectopic foci (electrical induction at unnatural locations which distort conduction) Occur spontaneously in regions outside the pacemaker. Ectopic foci caused by myocardial ischemia, excessive catecholamine release, cardiac glycoside toxicity and myocardial stretching. Slow acetylators tend to have much higher risk of drug-induced lupus. Not for long-term therapy (due to risk of dil - autimmune-mediated inflammation)

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30:718:409 Lecture 23: Antiarrhythmic Agents ver 1.0 Sakai 2018

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