11:709:255 Lecture Notes - Lecture 12: Gland, Dysgeusia, Keratoconjunctivitis
27 Jan 2020
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Document Summary
Chronic autoimmune disorder, leading to lymphocyte infiltration of the exocrine glands (salivary and lacrimal) Polyglandular tissue destruction: keratoconjunctivitis dry eyes (xerophthalmia, xerostomia thirst, cavities, gingivitis, dysgeusia, skin, connective tissue, lung, kidney, nerve, gi tissue destruction. May need to alter food consistency mechanically soft: bite sized pieces of food. Reduce chewing pain avoid hard, sticky, and chewy foods. Systemic hardening of the skin and visceral organs during deposition of fibrous ct: women affected more than men (4x) and may be genetic. Symptoms: nausea, vomiting, gerd, dysphagia, tooth loss, constipation, small intestine bacterial overgrowth, malabsorption. Autoimmune disease overproduction of interferon and other cytotoxic cells: most common in women of childbearing age. Signs and symptoms: fatigue, joint pain and swelling, fever, rashes, mouth ulcers, organ system failure. Widespread pain, diffuse tenderness, fatigue: not associated with inflammation or joint damage. Multidisciplinary: exercise, mnt, sleep hygiene, antidepressants (tricyclic antidepressants and ssris, cognitive behavior therapy. Weight control: may be impacted by antidepressants.
