11:709:255 Lecture Notes - Lecture 14: Rheumatoid Arthritis, Fibromyalgia, Public Health Genomics
27 Jan 2020
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Document Summary
More than 100 manifestations: gout, osteoarthritis, rheumatoid arthritis, temporomandibular disorders, sjogren"s syndrome, scleroderma, fibromyalgia and chronic fatigue syndrome, systemic lupus erythematosus (sle) Inflammation + loss of function of connective tissue and supporting body structures. Body"s immune system attacks its own tissues and cannot regulate intensity of immune response chronic inflammation. Can affect any part of the body. High risk for multiple autoimmune diseases with the presence of one (t1dm, celiac disease, ibs, ms) Consider nutrient-deficiencies related to medication side effects (folic acid, vitamin b12, iron, mg, k and b6) Consider muscle mass loss and wasting: increased calorie and protein needs. Phytonutrients (functional foods): tea, dark chocolate, turmeric, carotenoids, soy, sulfides/thiols: caution with high doses of antioxidants as they may over suppress natural immune response and increase risk for cvd and certain cancers. Aspirin (asa): inhibits cox-1 and cox-2 blocks production of prostaglandins (inflammation, pain) and thromboxanes (platelet aggregation) has gi side effects.
