01:694:301 Lecture Notes - Lecture 21: Glycogen Phosphorylase, Glycosidic Bond, Phosphorolysis

• School: Rutgers University
• Department: Molecular Biology and Biochemistry
• Course: 01:694:301
• Professor: F Deis

Document Summary

Chapter 21 glycogen metabolism": glucose is stored as a nonosmotically active polymer called glycogen, glycogen is a readily mobilized storage form of glucose. It is a large branched polymer of glucose residues that can be broken down to yield glucose when energy is needed. Most of these residues are linked by -1, 4 glycosidic linkages. Branched at about every 10th residues -1, 6 glycosidic linkages. 12 layers glucose molecules (as large as 40nm: doesn"t have as much energy as fatty acids; not as reduced, blood-glucose concentration maintained by glycogen glucose. It is the key enzyme in breakdown of glycogen. Phosphorylase is dimer containing 2 subunits: amino and carboxyl terminal domains: amino terminal contains glycogen binding site which located in deep crevice. These enyzmes (remodel) glycogen convert branched structure to linear paving the way for further cleavage by phosphorlyase: transferase shifts block of 3 glucosyl residues from outer branch to another branch.