01:694:301 Lecture 23: Chapter 23 - Protein Turnover and Amino Acid Catabolism (Revised)
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These amino groups converted to urea by urea cycle: amino carbon skeletons transformed to acetyl coa, acetoacetyl coa, pyr, or intermediates used cac. Other carbon skeletons glucose, glycogen, fats: dietary protein is vital source of amino acids; especially those containing essential aa", pvt mat hill. Ex: aminotransferase inc. asparate and alanine amino transferase: the resulting glutamate is then oxidatively deaminated by glutamate dh which can use either nad+ or nadp+. (rxn is driven fwd by rapid removal of nh4. Glutamate dh most easily detaches amino group; found in mitochondria. In mammals, glutamate allosterically inhibited by gtp/atp; stimulated adp/leu: the ammonia (nh4. +) produced is generally incorporated into urea for excretion. Ammonia is toxic if allowed to build up: you should understand how plp, pyridoxal phosphate works. Plp is the cofactor for very many amino acid reactions: plp is key coenzyme is aa degradation; formed schiff-base intermediates; allowing - amino groups to be shuttled b/w aa and keto acids.